This NACLA Report reflects on Central America’s past, present, and uncertain future. It is an effort to dissect a broad range of challenges, beyond questions of migration, plotting the region’s course. Authors grapple with the multiple and intersecting crises of the failures of neoliberalism, government corruption and mismanagement, political manipulation of grave security issues, climate chaos, and unfinished historical reckoning. They also distill Central Americans’ resilience and resistance in confronting these crises in each country of the Isthmus, providing ample food for thought for rethinking solidarity in the 21st century. One way of reading this issue is as a series of case studies in struggles to define Central America’s future against the backdrop of entrenched inequality.